MOTS-C Research Peptide
Mitochondria-derived peptide studied for metabolic regulation, insulin sensitivity, and longevity research
What is MOTS-C?
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-derived peptide encoded within the mitochondrial genome. It was discovered in 2015 and represents a novel class of signaling molecules that originate from mitochondria and communicate with the nucleus and other cellular compartments.
Researchers study MOTS-C for its remarkable effects on metabolic regulation, insulin sensitivity, exercise performance, and longevity pathways. It is considered one of the most exciting peptides in aging and metabolic research due to its unique mitochondrial origin and broad systemic effects in laboratory models.
מה זה פפטיד MOTS-C
MOTS-C הוא פפטיד הנגזר מהמיטוכונדריה, המקודד בגנום המיטוכונדריאלי. חוקרים חוקרים אותו בשל השפעותיו על ויסות מטבולי, רגישות לאינסולין ומסלולי אריכות ימים. הוא נחשב לאחד הפפטידים המרתקים ביותר במחקר ההזדקנות.
Mechanism of Action
AMPK Pathway Activation
MOTS-C activates AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis. This activation promotes glucose uptake, fatty acid oxidation, and mitochondrial biogenesis in research models.
Folate Cycle Regulation
MOTS-C inhibits the folate cycle and de novo purine synthesis, leading to AICAR accumulation which subsequently activates AMPK. This unique mechanism links mitochondrial function to nuclear gene expression.
Nuclear Translocation
Under stress conditions, MOTS-C translocates from the cytoplasm to the nucleus where it regulates stress-responsive gene expression, acting as a mitochondria-to-nucleus retrograde signal.
Insulin Sensitization
MOTS-C improves insulin sensitivity by enhancing glucose transporter expression and promoting glucose uptake in skeletal muscle and adipose tissue in laboratory models.
Research Areas Studied
Metabolic Regulation
Studies examine glucose metabolism, insulin sensitivity, and energy homeostasis in laboratory models.
Longevity Research
Research focuses on aging pathways, cellular stress responses, and lifespan extension mechanisms.
Exercise Performance
Investigations into physical endurance, muscle metabolism, and exercise-induced adaptations.
Obesity & Metabolic Disease
Studies on fat accumulation, metabolic syndrome markers, and obesity-related pathways in research models.
Half-Life Information
Short Half-Life: ~1-2 Hours
MOTS-C has a relatively short plasma half-life of approximately 1-2 hours in research models. Despite this short circulation time, its downstream effects on AMPK activation and gene expression can persist for extended periods.
The short half-life reflects the peptide's role as an acute signaling molecule. Research protocols typically use daily or twice-daily administration to maintain consistent metabolic signaling throughout the study period.
Storage Guidelines
Lyophilized (Powder) Storage
- Store at 2-8°C (refrigerated) for optimal stability
- Protect from light and moisture at all times
- Can be stored at -20°C for extended periods
- Shelf life: typically 24-36 months when properly stored
Reconstituted Solution Storage
- Store at 2-8°C immediately after reconstitution
- Protect from light using amber vials or foil wrap
- Use within 14-28 days depending on solvent used
- Do not freeze reconstituted solutions
Reconstitution Concept
MOTS-C is supplied as a lyophilized powder requiring reconstitution with a sterile solvent before use in research applications. Careful handling preserves the peptide's biological activity.
Select Appropriate Solvent
Bacteriostatic water is recommended for multi-dose use. Sterile water is suitable for single-use applications.
Add Solvent Slowly
Inject solvent down the side of the vial to minimize foaming and avoid direct contact with the powder.
Gentle Mixing
Swirl gently or roll the vial between hands. Never shake vigorously as this can denature the peptide.
Verify Complete Dissolution
Ensure the solution is clear with no visible particles before use in research protocols.
For detailed reconstitution protocols, refer to our Peptide Research Guides.
Frequently Asked Questions
What is MOTS-C peptide?
MOTS-C is a mitochondria-derived peptide encoded within the mitochondrial genome. It was discovered in 2015 and is studied for its effects on metabolic regulation, insulin sensitivity, exercise performance, and longevity pathways in laboratory models.
How does MOTS-C work?
MOTS-C activates AMPK through folate cycle inhibition and AICAR accumulation, translocates to the nucleus under stress conditions to regulate gene expression, and improves insulin sensitivity by enhancing glucose transporter expression.
What is MOTS-C studied for?
Research focuses on metabolic regulation, insulin sensitivity, longevity mechanisms, exercise performance, obesity-related pathways, and cellular stress responses in laboratory settings.
How should MOTS-C be stored?
Lyophilized MOTS-C should be stored at 2-8°C and protected from light. Once reconstituted, store refrigerated and use within 14-28 days depending on the solvent used.
What is the half-life of MOTS-C?
MOTS-C has a plasma half-life of approximately 1-2 hours in research models. Despite this short circulation time, its downstream effects on AMPK activation and gene expression can persist for extended periods.
Need More Information?
Contact our research team for detailed information about MOTS-C peptide.
Message on WhatsAppRelated Compounds
Research Use Only
All compounds are supplied strictly for laboratory research purposes only. Not intended for human consumption.