MGF

Mechano Growth Factor (MGF) is a splice variant of IGF-1 produced in response to mechanical stress on muscle tissue. This peptide has a unique C-terminal sequence that distinguishes it from systemic IGF-1. Researchers study MGF for its localized effects on muscle repair, satellite cell activation, and tissue regeneration.

Scientific research on MGF focuses on its role in mechanotransduction and muscle repair. Studies examine its effects on satellite cell proliferation, muscle fiber hypertrophy, protein synthesis, and tissue regeneration following mechanical stress. Researchers investigate its mechanisms involving local IGF-1 receptor activation, stem cell recruitment, and muscle-specific anabolic signaling in experimental models.