Melanotan 1

Melanotan 1 (Afamelanotide) is a synthetic tridecapeptide analogue of alpha-melanocyte stimulating hormone (α-MSH). This linear peptide has higher selectivity for MC1R compared to Melanotan 2. Researchers study Melanotan 1 for its effects on melanocortin-1 receptor activation and melanogenesis in laboratory models.

Research on Melanotan 1 focuses on its selective MC1R activation and melanogenic effects. Studies examine its influence on melanocyte function, eumelanin production, photoprotection mechanisms, and skin pigmentation. Researchers investigate its mechanisms involving MC1R signaling, tyrosinase activation, and melanin synthesis pathways in experimental settings.