AOD-9604 Research Peptide
Modified fragment of human growth hormone studied for lipolytic activity and fat metabolism research
What is AOD-9604?
AOD-9604 is a modified fragment of the human growth hormone (hGH) C-terminus, specifically the amino acid sequence 177–191. It was developed to isolate the lipolytic (fat-burning) properties of growth hormone without the anabolic or insulin-desensitizing effects associated with full-length hGH.
Researchers study this peptide to understand how specific fragments of growth hormone influence fat metabolism, adipogenesis, and energy regulation in laboratory models. Its targeted mechanism makes it a valuable tool for metabolic research.
מה זה פפטיד AOD-9604
AOD-9604 הוא שבר מוגדר של הורמון הגדילה האנושי, הנחקר בשל השפעותיו על חילוף החומרים של שומן ופעילות ליפוליטית. פפטיד זה מאפשר לחוקרים לבחון את מנגנוני פירוק השומן ללא ההשפעות האנבוליות של הורמון הגדילה המלא.
Mechanism of Action
Lipolytic Activity
AOD-9604 stimulates lipolysis — the breakdown of stored fat — by activating beta-3 adrenergic receptors in adipose tissue, promoting the release of free fatty acids for energy use.
Inhibition of Lipogenesis
The peptide inhibits lipogenesis (new fat formation) by modulating key enzymes involved in fatty acid synthesis, helping to regulate overall fat accumulation in research models.
No Insulin Resistance
Unlike full-length hGH, AOD-9604 does not appear to affect insulin sensitivity or blood glucose regulation, making it a cleaner tool for studying isolated fat metabolism pathways.
Cartilage & Bone Research
Emerging research also investigates AOD-9604 for potential effects on cartilage repair and bone metabolism, expanding its research applications beyond metabolic studies.
Research Areas Studied
Fat Metabolism
Studies examine lipolytic activity, free fatty acid release, and adipose tissue dynamics in laboratory models.
Body Composition
Research focuses on changes in fat mass, lean mass ratios, and overall body composition parameters.
Adipogenesis Regulation
Investigations into the inhibition of new fat cell formation and adipocyte differentiation pathways.
Cartilage Research
Emerging studies on potential effects on cartilage repair and joint tissue health in experimental models.
Half-Life Information
Short Half-Life: ~30 Minutes
AOD-9604 has a short biological half-life of approximately 30 minutes in research models. This rapid clearance means the peptide acts quickly and is eliminated from the system relatively fast.
Research protocols typically account for this short half-life by using multiple daily administrations to maintain consistent lipolytic signaling throughout the study period.
Storage Guidelines
Lyophilized (Powder) Storage
- Store at 2-8°C (refrigerated) for optimal stability
- Protect from light and moisture at all times
- Can be stored at -20°C for extended periods
- Shelf life: typically 24-36 months when properly stored
Reconstituted Solution Storage
- Store at 2-8°C immediately after reconstitution
- Protect from light using amber vials or foil wrap
- Use within 14-28 days depending on solvent used
- Do not freeze reconstituted solutions
Reconstitution Concept
AOD-9604 is supplied as a lyophilized powder requiring reconstitution with a sterile solvent before use in research applications.
Select Appropriate Solvent
Bacteriostatic water is recommended for multi-dose use. Sterile water is suitable for single-use applications.
Add Solvent Slowly
Inject solvent down the side of the vial to minimize foaming and avoid direct contact with the powder.
Gentle Mixing
Swirl gently or roll the vial between hands. Never shake vigorously as this can denature the peptide.
Verify Complete Dissolution
Ensure the solution is clear with no visible particles before use in research protocols.
For detailed reconstitution protocols, refer to our Peptide Research Guides.
Frequently Asked Questions
What is AOD-9604 peptide?
AOD-9604 is a modified fragment of human growth hormone (amino acids 177–191) studied for its lipolytic properties. It is designed to isolate fat-burning activity without the anabolic effects of full-length hGH.
How does AOD-9604 work?
AOD-9604 stimulates lipolysis by activating beta-3 adrenergic receptors in adipose tissue and inhibits lipogenesis by modulating fatty acid synthesis enzymes, without significantly affecting insulin sensitivity.
What is AOD-9604 studied for?
Research focuses on fat metabolism, adipogenesis regulation, body composition changes, and emerging studies on cartilage and bone tissue in laboratory settings.
How should AOD-9604 be stored?
Lyophilized AOD-9604 should be stored at 2-8°C and protected from light. Once reconstituted, store refrigerated and use within 14-28 days depending on the solvent used.
What is the half-life of AOD-9604?
AOD-9604 has a short half-life of approximately 30 minutes, requiring multiple daily administrations in research protocols to maintain consistent lipolytic signaling.
Need More Information?
Contact our research team for detailed information about AOD-9604 peptide.
Message on WhatsAppRelated Compounds
Research Use Only
All compounds are supplied strictly for laboratory research purposes only. Not intended for human consumption.